![]() ![]() However, the causal relationship between variations in biomarkers and the specific cellular dysfunction or phenotypes related to aging remains largely unknown. Based on the advantages, numerous association studies on human aging have conducted with blood samples, and revealed aging-related changes in DNA methylation 12, 13, 14, 15, 16 and gene expression 15, 16, 17, 18, 19, and their application as biological clocks to estimate chronological age from the identified aging signatures 20, 21. In particular, blood is easier to collect from living human body than other tissues, and also actively studied in forensic science to estimate the age of suspects 10, 11. With the development of next-generation sequencing (NGS) technologies, molecular genetic studies have accumulated large quantities of omics data on aging and aging-related diseases 7, 8, 9. Clinical studies of human aging have identified aging-related biomarkers associated with metabolic disorder 1, loss of skeletal muscle 2, neurodegeneration 3, skin wrinkles 4, and hair loss 5 as well as an increased risk of aging-related diseases 6, 7 such as type 2 diabetes, cancers, and Alzheimer’s disease. ![]() ![]() Collectively, our results demonstrate the utility of a network model for integrative analysis of omics data, which can help elucidate inter-omics regulatory mechanisms and develop therapeutic strategies against aging.Īging is a process that accompanies external (physical appearance) and internal (physiological functions) changes in an organism, which are affected by molecular interactions across multiple omics layers. Despite insufficient data on the binding targets of perturbagens and their modes of action, curcumin, which reversely regulated the biomarkers in the experimental dataset, was found to bind and inhibit JUN, which was identified as a candidate target via signal flow analysis. For validation, we screened public experimental data including gene expression profiles in response to thousands of chemical perturbagens. We also identified candidate molecular targets that can reversely regulate the transcriptomic biomarkers of aging by reconstructing a gene regulatory network model and performing signal flow analysis. In this study, we conducted next-generation sequencing of DNA methylation and RNA sequencing of blood samples from 51 healthy adults between 20 and 74 years of age and identified aging-related epigenetic and transcriptomic biomarkers. Previous studies have identified numerous molecular biomarkers involved in these changes, but their regulatory mechanisms and functional repercussions remain elusive. The artwork will be on display as part of the Masters Show in the Cooper Gallery at Duncan of Jordanstone College until 18 September.Aging is associated with widespread physiological changes, including skeletal muscle weakening, neuron system degeneration, hair loss, and skin wrinkling. "The combination of forensic science and art is one which has fantastic potential - the sort of potential we are seeing realised by our students." Senior lecturer Dr Caroline Wilkinson added: "Our work crosses all sorts of boundaries, from current criminal investigations to delving into history, and from developing facial recognition software to, as we see in the Masters Show, developing a new surgical training model for the other end of the body, helping train clinicians in colo-rectal cancer procedures. I know many professionals, myself included, who wish this course had been available at the start of their careers." "They will leave as the most highly qualified new practitioners in this field. He said: "I am delighted to see our first cohort of graduates come through the course with such an interesting and varied range of projects. They use techniques like facial reconstruction, age progression and composite art.Ĭonvener of the course at Dundee University, Greg Mahoney, worked as a forensic artist in the Boston Police Department for more than 20 years. The pieces include the reconstructed face of an Egyptian mummy and new portraits of 18th century criminals.įorensic artists can help agencies like the police build up an idea of what a suspect or a victim would have looked like even if many years have passed. The first graduates from the world's only degree course in Forensic Art are displaying their work in Dundee. One student has reconstructed the face of an Egyptian mummy ![]()
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